كولشيسين
| Kind | API |
|---|---|
| Class | Antigout agent — anti-inflammatory alkaloid (tubulin/microtubule inhibitor) |
| Synonyms | Colchicinum |
| Common uses / forms | Tablets; acute gout flares, familial Mediterranean fever, pericarditis |
| Properties | Alkaloid extracted from Gloriosa superba / Colchicum autumnale; binds tubulin; narrow therapeutic index and highly toxic in overdose; water-soluble |
| Compendia | USP, EP, BP |
| Sourcing origins | India, China, EU |
| Dominant inbound route | Hormuz |
| Indicative price band | $$$$ (> $1000 / kg) |
| Indicative lead time | long (80–120+ days) |
| Notes | Botanical extraction (Gloriosa superba seeds, India-dominant) — supply is harvest/yield-dependent and concentrated in few extractors, but several qualified sources exist so not single-source; narrow-TI potent alkaloid needs tight related-substance control and careful handling. |
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Cite as: AUPAM Experts' Office, Colchicine — sourcing profile (API) — AUPAM Data Bank, retrieved 2026-08-31, https://aupameo.org/datasets/databank/a-colchicine.html