Tenofovir disoproxil fumarate

تينوفوفير ديسوبروكسيل فومارات

KindAPI
ClassAntiviral — nucleotide reverse transcriptase inhibitor (NtRTI)
SynonymsTDF, Tenofovir DF, Bis(POC)-PMPA fumarate, PMPA prodrug
Common uses / formsOral tablets for HIV-1 and chronic hepatitis B; backbone of fixed-dose combinations (with lamivudine/emtricitabine, efavirenz, or dolutegravir as TLD)
PropertiesBCS Class III (high solubility, low permeability); disoproxil di-ester prodrug of tenofovir; hygroscopic and hydrolysis-sensitive with a low melting point; tight moisture control required
CompendiaUSP, EP, BP, IP
Sourcing originsIndia, China
Dominant inbound routeHormuz
Indicative price band$$ ($10–100 / kg)
Indicative lead timemedium (50–80 days)
NotesMoisture-sensitive prodrug; monoester and free-tenofovir degradants need tight limits; dominant multi-source Indian generic API
Indicative planning bands for reference/education — not supplier quotes. Sourcing routes reflect the dominant inbound lane to the Arab region.

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Cite as: AUPAM Experts' Office, Tenofovir disoproxil fumarate — sourcing profile (API) — AUPAM Data Bank, retrieved 2026-08-31, https://aupameo.org/datasets/databank/a-tenofovir-disoproxil-fumarate.html