كلوروبيوتانول
| Kind | Excipient |
|---|---|
| Class | Antioxidants, chelators & preservatives — antimicrobial preservative (halogenated alcohol) |
| Synonyms | chlorobutanol, chlorbutanol, 1,1,1-trichloro-2-methyl-2-propanol, trichloro-tert-butanol, acetone chloroform |
| Common uses / forms | Antimicrobial preservative for ophthalmics, injectables and some topicals; anhydrous and hemihydrate grades; typical up to ~0.5% |
| Properties | White volatile crystals, sublimable, slightly water-soluble; stable only at acidic pH, hydrolyzes above ~pH 5.5 and on heating; camphor-like odor |
| Compendia | USP, EP, BP, JP |
| Sourcing origins | China, India, EU |
| Dominant inbound route | Hormuz |
| Indicative price band | $$$ ($100–1000 / kg) |
| Indicative lead time | medium (50–80 days) |
| Notes | Compendial as Chlorobutanol (JP included). Narrower producer base than commodity preservatives; large volatile losses through plastic and on autoclaving; specify hemihydrate vs anhydrous; keep formulation acidic to retain activity |
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Cite as: AUPAM Experts' Office, Chlorbutol — sourcing profile (Excipient) — AUPAM Data Bank, retrieved 2026-08-31, https://aupameo.org/datasets/databank/e-chlorbutol.html