أسيتات سكسينات الهيدروكسي بروبيل ميثيل سيلولوز
| Kind | Excipient |
|---|---|
| Class | Enteric polymer / solid-dispersion carrier |
| Synonyms | HPMCAS, Hypromellose acetate succinate, AQOAT, Affinisol HPMCAS |
| Common uses / forms | Enteric coats and amorphous solid-dispersion carrier for poorly-soluble APIs; L/M/H grades by dissolution pH |
| Properties | Anionic cellulose ester; pH-triggered solubility (5.5–6.8); non-phthalate; hot-melt/spray-dry compatible |
| Compendia | USP, EP, JP |
| Sourcing origins | Japan, USA |
| Dominant inbound route | Hormuz |
| Indicative price band | $$$ ($100–1000 / kg) |
| Indicative lead time | long (80–120+ days) |
| Supply flag | Single-source — concentrated supplier base; plan a second source |
| Notes | Concentrated supply (Shin-Etsu/Ashland); qualify early |
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Cite as: AUPAM Experts' Office, Hypromellose acetate succinate (HPMCAS) — sourcing profile (Excipient) — AUPAM Data Bank, retrieved 2026-08-31, https://aupameo.org/datasets/databank/e-hypromellose-acetate-succinate-hpmcas.html