Low-substituted hydroxypropyl cellulose

هيدروكسي بروبيل سيلولوز منخفض الاستبدال

Kind	Excipient
Class	Disintegrant / binder
Synonyms	L-HPC, LH-11, LH-21, LH-31, low-substituted HPC
Common uses / forms	Disintegrant and dry/wet-granulation binder in tablets; 2–10% w/w
Properties	White partially substituted hydroxypropyl ether of cellulose; water-insoluble, swells; dual binder-disintegrant action
Compendia	USP, EP, BP, JP
Sourcing origins	JP
Dominant inbound route	Hormuz
Indicative price band	$$$ ($100–1000 / kg)
Indicative lead time	long (80–120+ days)
Supply flag	Single-source — concentrated supplier base; plan a second source
Notes	Dominated by Japanese manufacture (Shin-Etsu); qualify second source early

Indicative planning bands for reference/education — not supplier quotes. Sourcing routes reflect the dominant inbound lane to the Arab region.

Related substances (Disintegrant / binder)

Guar gum

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Cite as: AUPAM Experts' Office, Low-substituted hydroxypropyl cellulose — sourcing profile (Excipient) — AUPAM Data Bank, retrieved 2026-08-31, https://aupameo.org/datasets/databank/e-low-substituted-hydroxypropyl-cellulose.html